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Archive for July, 2010

Prostate Cancer Discovered in 40% of Men Who Test Negative for the Disease

State-of-the-art biopsy procedure is catching

prostate cancer that hasn’t been diagnosed

Westmont, IL, January 18, 2008 Forty percent of men with prostate cancer may not even know they have it, according to a new research study by the Prostate Cancer Foundation of Chicago.  The study revealed the standard office biopsy procedure often isn’t enough to properly detect prostate cancer.

This new research will be published in an upcoming issue of Urology, a national medical journal.

Researchers used an advanced biopsy technique called stereotactic transperineal prostate biopsy (STPB).  This was performed on patients with persistent elevated prostate specific antigen (PSA) levels who previously had at least one negative office biopsies.  All patients had received transrectal prostate biopsies (TRPB), administered by a urologist.

“Men who have negative transrectal biopsies and continue to have elevated PSA levels should consider STPB because 40% will harbor malignancy, “says Michelle Braccioforte, director of research and education for the Prostate Cancer Foundation of Chicago.  “Our level of confidence is greatly enhanced with regards to the presence or absence of cancer, and more specifically, the exact location of the cancer within the prostate.”

STPB is performed by taking a median of 40 samples of the prostate through the perineum while the patient is under general anesthesia.  Performed as an outpatient procedure, it allows more comprehensive sampling, compared to the transrectal method, which takes fewer samples through the rectum.  In addition, by taking more samples during STPB, the exact location of the cancer can be pinpointed.

Between April 2004 and January 2008, 747 patients with high PSA levels were studied. All patients had been tested using TRPB at least once and all results had been negative.  All patients received the STPB.  Biopsy results identified the presence of cancer in 291 (39%) of the patients.

One in six men in the U.S. will be diagnosed with prostate cancer, the most common form of cancer among men.  For those with elevated or rising PSA levels, this is a sign that further testing should be administered to rule out prostate cancer.

“The information obtained from this kind of comprehensive biopsy allows us to design and perform more sophisticated treatment plans”, says Dr. Brian Moran, medical director of the Prostate Cancer Foundation of Chicago and the Chicago Prostate Cancer Center.  This procedure is also a stepping stone towards focal therapy, where more limited treatment can result in less side effects, yet achieve cure rates equal to more radical forms of treatment. ”

The Prostate Cancer Foundation of Chicago, located in Westmont, IL, is a not-for-profit organization that conducts ongoing research intended to improve the diagnosis and treatment of prostate cancer.  For more information, or to obtain a white paper of the “Stereotactic Transperineal Prostate Biopsy,” please visitwww.chicagoprostatefoundation.org to download or call Michelle at 630.654.2515.

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Swedish Study Concludes Prostate Cancer Screening Reduces Deaths by 50%

An article was recently published summarizing the results of a 14 year study by the University of Gothenburg in Sweden on prostate cancer screening.  The article, written by Kristen Hallam, states that PSA testing for prostate cancer helped reduce prostate cancer deaths by 50% after 14 years of study.  Of 10,000 men screened using PSA tests every 2 years, 44 died of prostate cancer.  The other 10,000 men in the study were not given PSA tests and 78 of them died of prostate cancer.  Total deaths were almost identical in both groups with 1,981 deaths in the screening group and 1,982 in the non-screening group. The study also found that 11.4% of men in the screening group and 7.2% of the non-screening group were diagnosed with prostate cancer.

There has been much debate over whether there has been too much screening for prostate cancer, which some feel results in unnecessary treatment of the disease that can impair quality of life.  However, Chicago Prostate Cancer Center highly recommends annual PSA screening accompanied by digital rectal exams for men over the age of 50.  (African American men and men with a family history of prostate cancer should begin screening at the age of 40.)  Prostate cancer is much easier to treat and cure in the early stages, which can be detected by screening.

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